Genomics and Computational Biology (GCB)

GCB 493 Epigen of Health&Disease

Also Offered As: BIOL 493

Activity: Seminar

1 Course Unit

GCB 534 Experimental Genome Science

This course will survey methods and questions in experimental genomics, including next generation sequencing methods, genomic sequencing in humans and model organisms, functional genomics, proteomics, and applications of genomics methods. Students will be expected to review and discuss current literature and to propose new experiments based on material learned in the course.

Taught by: C Brown, J Murray

Also Offered As: PHRM 534

Prerequisites: Undergraduates and Masters students need BIOL431 or equivalent

Activity: Lecture

1 Course Unit

GCB 535 Introduction to Bioinformatics

This course provides overview of bioinformatics and computational biology as applied to biomedical research. A primary objective of the course is to enable students to integrate modern bioinformatics tools into their research activities. Course material is aimed to address biological questions using computational approaches and the analysis of data. A basic primer in programming and operating in a UNIX enviroment will be presented, and students will also be introduced to Python, R, and tools for reproducible research. This course emphasizes direct, hands-on experience with applications to current biological research problems. Areas include DNA sequence alignment, genetic variation and analysis, motif discovery, study design for high-throughput sequencing, RNA, and gene expression, single gene and whole-genome analysis, machine learning, and topics in systems biology. The relevant principles underlying methods used for analysis in these areas will be introduced and discussed at a level appropriate for biologists without a background in computer science. The course is not intended for computer science students who want to learn about biologically motivaetd algorithmic problems; BIOL 437/GCB 536 and GCB/CIS/BIOL537 are more appropriate.

Taught by: B Voight,C Greene

Course usually offered in spring term

Also Offered As: CIS 535, MTR 535, PHRM 535

Prerequisites: The course will assume a solid knowledge of modern biology. An advanced undergraduate course such as BIOL 421 or a graduate course in biology such as BIOL 526 (Experimental Principles in Cell and Molecular Biology), BIOL527 (Advanced Molecular Biology and Genetics), BIOL 528 (Advanced Molecular Genetics), BIOL 540 (Genetic Systems, or equivalent, is a prerequisite.

Activity: Lecture

1 Course Unit

Notes: All students are required to bring a laptop to the lab sessions (Fridays). TAs will provide help with the material, but students should be computer-capable with their own laptop, and should be willing/capable to download and install free software from the internet.

GCB 536 Computational Biology

An introductory computational biology course designed for computational scientists. The course will cover fundamentals of algorithms, statistics, and mathematics as applied to biological problems. In particular, emphasis will be given to biological problem modeling. Students will be expected to learn the basic algorithms underlying computational biology, basi c mathematical / statistical proofs and molecular biology. Topics to be cover ed are genome annotation and string algorithms, pattern search and statistical learning, molecular evolution and phylogenetics and small molecule folding.

Course not offered every year

Also Offered As: BIOL 437

Activity: Lecture

1 Course Unit

GCB 537 Advanced Computational Biology

1. Learn important concepts/methods from statistical data analysis and machine learning as they are applied to computational biology. 2. Learn about current topics in genomics and computational biology through in depth discussion of both classic and recent papers. 3. Gain hands on experience in data analysis, coding and evaluating tools/algorithms as they apply to topics covered in class. 4. Learn to evaluate, criticize, summarize, and present research papers in genomics and computational biology.

Taught by: Y Barash, R Faryabi

Course usually offered in spring term

Also Offered As: BIOL 537, CIS 635

Prerequisite: GCB536 or equivalent

Activity: Seminar

1 Course Unit

Notes: This is not a bioinformatics lab. Non-GCB students need to be approved by instructors

GCB 567 Modeling Biol Systems

Also Offered As: BE 567

Activity: Lecture

1 Course Unit

GCB 585 Wistar Inst Cancer Biol

Also Offered As: BMB 585

Activity: Lecture

1 Course Unit

GCB 752 Genomics

Taught by: S Diskin

Course usually offered in spring term

Also Offered As: CAMB 752

Prerequisites: GCB 534 or equivalent, or permission from instructor

Activity: Seminar

1 Course Unit